Socialization, and its modulation by sex, on the development and recovery of activity-based anorexia in rats

Martínez-Herrada, Antonio, Paz, Ana de y Pellón Suárez de Puga, Ricardo . (2023) Socialization, and its modulation by sex, on the development and recovery of activity-based anorexia in rats. Physiology and Behavior, 270, 114271

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Título Socialization, and its modulation by sex, on the development and recovery of activity-based anorexia in rats
Autor(es) Martínez-Herrada, Antonio
Paz, Ana de
Pellón Suárez de Puga, Ricardo
Materia(s) Psicología
Abstract The activity-based anorexia (ABA) animal model has been used in the laboratory to study the role of excessive physical activity in the manifestation of anorexia nervosa (AN) in humans. Factors of social context are crucial in human health and the emergence of many psychological disorders, which have also been observed in studies using different mammal species that, like human beings, set their lives in groups. In the present study, the animals’ social condition was manipulated to observe the effect of socialization in ABA development, and the possible different influence of the variable sex on the phenomenon. Eighty Wistar Han rats were distributed into four male and four female groups with 10 subjects each, manipulating social conditions (group housing or social isolation) and physical activity (access or not to a running wheel). Throughout the procedure, all groups had food restricted to 1 h/day during the light period. Furthermore, ABA experimental groups with access to the running wheel had two periods of access to the wheel of 2 h each, one before and the other after the food period. In this experiment, socialized rats were less vulnerable to weight loss during the procedure, although there were no differences between the ABA groups. Moreover, social enrichment was shown to be an enabling variable of the animals’ recovery after their withdrawal from the procedure, with this effect being more pronounced in females. The results in this study suggest the need to further in the analysis of the role of socialization in the development of ABA.
Palabras clave Anorexia nervosa
Activity-based anorexia
Socialization
Excessive activity
Sex differences
Recovery
Rats
Editor(es) Elsevier
Fecha 2023-07-17
Formato application/pdf
Identificador bibliuned:DptoPBI-FPSI-Articulos-Rpellon-0005
http://e-spacio.uned.es/fez/view/bibliuned:DptoPBI-FPSI-Articulos-Rpellon-0005
DOI - identifier https://doi.org/10.1016/j.physbeh.2023.114271
ISSN - identifier 0031-9384 - eISSN: 1873-507X
Nombre de la revista Physiology and Behavior
Número de Volumen 270
Publicado en la Revista Physiology and Behavior, 270, 114271
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Physiology and Behavior, is available online at the publisher's website: https://doi.org/10.1016/j.physbeh.2023.114271
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Physiology and Behavior, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.physbeh.2023.114271

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Creado: Thu, 08 Feb 2024, 08:14:17 CET