Depression as a Risk Factor for Dementia: A Meta-Analysis

Fernández Fernández, Roberto, Íbias, Javier y Maciá Antón, María Araceli . (2023) Depression as a Risk Factor for Dementia: A Meta-Analysis. The Journal of Neuropsychiatry and Clinical Neurosciences

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Título Depression as a Risk Factor for Dementia: A Meta-Analysis
Autor(es) Fernández Fernández, Roberto
Íbias, Javier
Maciá Antón, María Araceli
Materia(s) Psicología
Abstract Dementia is a syndrome characterized by the deterioration of cognitive function beyond what is expected. The increased risk of developing this syndrome resulting from established modifiable risk factors, such as depressive episodes, is currently a subject of interest. The aim of this study was to review the scientific evidence that addresses the relationship between depression and dementia. A bibliographic search of the PubMed and PsycInfo databases for articles published over the past 20 years was conducted with the following medical subject heading terms: depression or depressive, dementia, and incidence or cohort studies. After articles meeting the inclusion criteria were selected, relevant moderating variables were grouped as sample characteristics, methodological characteristics, extrinsic characteristics, and outcome variables. The 26 selected studies resulted in a sample comprising 1,760,262 individuals. Statistical analysis revealed a pooled relative risk for the development of dementia of 1.82 (95% CI=1.62–2.06). The primary variables evaluated were the diagnostic methods for depression and dementia and the presence of depression. Other variables, such as mean age, methodological quality of each study, follow-up time, and publication year, were also evaluated. Age was statistically but not clinically significant. No relevant publication bias or alterations in the results were found when accounting for the quality of the studies. It is recommended that new moderating variables be evaluated or that existing variables be reformulated in future studies.
Palabras clave Alzheimer’s Disease
Dementia
Depression
Meta-Analysis
Risk Ratio
1545-7222
Editor(es) Psychiatry Online
Fecha 2023-12-19
Formato application/pdf
Identificador bibliuned:DptoMCC-FPSI-Articulos-Jibias-0005
http://e-spacio.uned.es/fez/view/bibliuned:DptoMCC-FPSI-Articulos-Jibias-0005
DOI - identifier 10.1176/appi.neuropsych.20230043
ISSN - identifier 1545-7222
Nombre de la revista The Journal of Neuropsychiatry and Clinical Neurosciences
Publicado en la Revista The Journal of Neuropsychiatry and Clinical Neurosciences
Idioma eng
Versión de la publicación submittedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales This is an Manuscript of an article published by Psychiatry Online in The Journal of Neuropsychiatry and Clinical Neurosciences, available at: https://doi.org/10.1176/appi.neuropsych.20230043
Notas adicionales Este es el manuscrito del artículo publicado por Psychiatry Online en The Journal of Neuropsychiatry and Clinical Neurosciences, disponible en línea: https://doi.org/10.1176/appi.neuropsych.20230043

 
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Creado: Wed, 07 Feb 2024, 02:15:20 CET