Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats

Espinoza Serrano, Nidia, Saputra, Samuel G., Íbias, Javier, Company, Matthew y Nazarian, Arbi . (2021) Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats. Psychopharmacology


Título Pain-induced impulsivity is sexually dimorphic and mu-opioid receptor sensitive in rats
Autor(es) Espinoza Serrano, Nidia
Saputra, Samuel G.
Íbias, Javier
Company, Matthew
Nazarian, Arbi
Materia(s) Psicología
Abstract Rationale and objectives Pain sensation can negatively impact cognitive function, including impulsivity. Pain-induced changes in impulsivity can contribute to development of psychiatric comorbidities found in those with chronic pain conditions. The goal of this study was to determine whether complete Freund’s adjuvant (CFA)-induced pain manipulation enhances impulsivity in rats. Whether the pain-induced impulsivity is sexually dimorphic, and if mu-opioid receptors play a role in these processes. Methods Male and female rats were screened for trait impulsivity and designated as high or low impulsive using a delay discounting task. Rats then received a hind paw injection of CFA, and their impulsivity was assessed for 16 days. The effects of morphine on impulsivity were also examined. In a separate experiment, rats were pretreated with beta-funaltrexamine (β-FNA) to determine the role of mu-opioid receptors on impulsivity. Results CFA treatment increased impulsivity in males and females. The onset of CFA-induced impulsivity was faster in high impulsive females than males. Morphine blocked CFA-induced impulsivity in both sexes in a dose- and time-dependent manner. β-FNA prevented the actions of morphine on CFA-induced impulsivity in high impulsive males, but not high impulsive females. Moreover, β-FNA increased CFA-induced impulsivity in morphine naïve males, but not females. Conclusion These findings demonstrate unique sex differences in CFA-induced impulsivity, response to morphine, and the impact of mu-opioid receptors. A better understanding of cognitive deficits and their mechanisms can provide insight into the development of substance abuse and psychiatric comorbidities that occur in people with chronic pain.
Palabras clave Delay discounting
Opioid
Impulsivity
Pain
Sex difference
Editor(es) Springer Nature
Fecha 2021-08-24
Formato application/mp3
Identificador bibliuned:DptoMCC-FPSI-Articulos-Jibias-0004
http://e-spacio.uned.es/fez/view/bibliuned:DptoMCC-FPSI-Articulos-Jibias-0004
DOI - identifier 10.1007/s00213-021-05963-z
ISSN - identifier 1432-2072
Nombre de la revista Psychopharmacology
Número de Volumen 238
Página inicial 3447
Página final 3462
Publicado en la Revista Psychopharmacology
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales This is an Accepted Manuscript of an article published by Springer Nature in Psychopharmacology, available at: https://doi.org/10.1007/s00213-021-05963-z
Notas adicionales Este es el manuscrito aceptado del artículo publicado por Springer Nature en Psychopharmacology, disponible en línea: https://doi.org/10.1007/s00213-021-05963-z

 
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Creado: Wed, 07 Feb 2024, 02:08:12 CET