Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes

Íbias, Javier, O’Dell, Laura E. y Nazarian, Arbi . (2018) Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes. Behavioural Brain Research

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Título Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes
Autor(es) Íbias, Javier
O’Dell, Laura E.
Nazarian, Arbi
Materia(s) Psicología
Abstract The rewarding effects of nicotine have been previously shown to be enhanced in rodent models of diabetes. It is presently unclear whether the enhanced nicotine reward observed in the diabetes models are mediated via an insulin or glucose mechanism. This study examined whether the enhanced rewarding effects of nicotine observed in streptozotocin (STZ)-treated rats are insulin-mediated. Male and female rats were treated with STZ and the rewarding effects of nicotine (0.2 mg/kg) were measured using the conditioned place preference (CPP) procedure. Some STZ-treated animals received insulin supplementation via subcutaneous pellets immediately after STZ administration, while other rats received daily injections of dapagliflozin (10 mg/kg), a sodium-glucose cotransporter-2 inhibitor. Both male and female STZ-treated rats displayed hyperglycemia, and their blood glucose levels (BGLs) were normalized to control levels following insulin supplementation or dapagliflozin administration. STZ-treated male rats displayed higher nicotine CPP relative to vehicle-treated controls. This effect was abolished in rats that received insulin supplementation or dapagliflozin administration. STZ-treated female rats displayed reduced levels of nicotine CPP as compared to male rats, regardless of treatment condition. These results suggest that glucose plays a major role in modulating the rewarding effects of nicotine in male rats treated with STZ.
Palabras clave Streptozotocin
Insulin
Dapagliflozin
Hyperglycemia
Diabetes
Place preference
Editor(es) Elsevier
Fecha 2018-10-01
Formato application/pdf
Identificador bibliuned:DptoMCC-FPSI-Articulos-Jibias-0002
http://e-spacio.uned.es/fez/view/bibliuned:DptoMCC-FPSI-Articulos-Jibias-0002
DOI - identifier 10.1016/j.bbr.2018.05.018
ISSN - identifier 0166-4328
Nombre de la revista Behavioural Brain Research
Número de Volumen 351
Página inicial 75
Página final 82
Publicado en la Revista Behavioural Brain Research
Idioma eng
Versión de la publicación submittedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales This is an Manuscript of an article published by Elsevier in Behavioural Brain Research, available at: https://doi.org/10.1016/j.bbr.2018.05.018
Notas adicionales Este es el manuscrito del artículo publicado por Elsevier en Behavioural Brain Research, disponible en línea: https://doi.org/10.1016/j.bbr.2018.05.018

 
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Creado: Wed, 07 Feb 2024, 01:52:25 CET