The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD

Íbias, Javier, Daniels, Carter W., Miguéns, Miguel, Pellón, Ricardo y Sanabria, Federico . (2017) The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD. Behavioural Brain Research

Ficheros (Some files may be inaccessible until you login with your e-spacio credentials)
Nombre Descripción Tipo MIME Size
IBIAS_MARTIN_JAVIER_The_Effect_of.pdf IBIAS_MARTIN_JAVIER_The_Effect_of.pdf application/pdf 485.29KB

Título The Effect of Methylphenidate on the Microstructure of Schedule-Induced Polydipsia in an animal model of ADHD
Autor(es) Íbias, Javier
Daniels, Carter W.
Miguéns, Miguel
Pellón, Ricardo
Sanabria, Federico
Materia(s) Psicología
Abstract Schedule-induced polydipsia (SIP) was established in spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY), and Wistar rats, using a multiple fixed-time (FT) schedule of food delivery, with 30- and 90-s components. Thereafter, animals were exposed to methylphenidate (MPH; 2.5 mg/kg/d) for six consecutive SIP sessions. A test to assess possible sensitization effects was also conducted four days after termination of the drug treatment. At baseline, FT 90-s produced longer and more frequent drinking episodes in SHR than in WKY. An analysis of the distribution of inter-lick intervals revealed that drinking was organized in bouts, which were shorter in SHR than in WKY. Across strains and schedules, MPH shifted drinking episodes towards the beginning of inter-food intervals, which may reflect a stimulant effect on SIP. MPH transiently reduced the frequency of drinking episodes in WKY in FT 30-s, and more permanently reduced the frequency of licking bouts in Wistar rats. MPH also increased the length of licking bouts in Wistar rats. Overall, SHR displayed a hyperactive-like pattern of drinking (frequent but short bouts), which 2.5 mg/kg MPH appears to reduce in WKY and Wistar but not in SHR rats. It appears that therapeutic effects of MPH on hyperactive-like SIP require higher doses in SHR relative to control strains.
Palabras clave Schedule-induced polydipsia
Methylphenidate
Attention-deficit hyperactivity disorder Bouts
Spontaneously hypertensive rat
Wistar Kyoto rats
Editor(es) Elsevier
Fecha 2017-08-30
Formato application/pdf
Identificador bibliuned:DptoMCC-FPSI-Articulos-Jibias-0001
http://e-spacio.uned.es/fez/view/bibliuned:DptoMCC-FPSI-Articulos-Jibias-0001
DOI - identifier 10.1016/j.bbr.2017.06.048
ISSN - identifier 0166-4328
Nombre de la revista Behavioural Brain Research
Número de Volumen 333
Página inicial 211
Página final 217
Publicado en la Revista Behavioural Brain Research
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales This is an Accepted Manuscript of an article published by Elsevier in Behavioural Brain Research, available at: https://doi.org/10.1016/j.bbr.2017.06.048
Notas adicionales Este es el manuscrito aceptado del artículo publicado por Elsevier en Behavioural Brain Research, disponible en línea: https://doi.org/10.1016/j.bbr.2017.06.048

 
Versiones
Versión Tipo de filtro
Contador de citas: Google Scholar Search Google Scholar
Estadísticas de acceso: 45 Visitas, 1 Descargas  -  Estadísticas en detalle
Creado: Wed, 07 Feb 2024, 01:47:16 CET