Effects at molecular level of multi-walled carbon nanotubes (MWCNT) in Chironomus riparius (DIPTERA) aquatic larvae

Martínez Paz, Pedro, Negri, Viviana, Esteban Arranz, Adrian, Martínez Guitarte, José Luis, Ballesteros, Paloma y Morales, Mónica . (2019) Effects at molecular level of multi-walled carbon nanotubes (MWCNT) in Chironomus riparius (DIPTERA) aquatic larvae. Aquatic Toxicology Volume 209, April 2019, Pages 42-48

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Título Effects at molecular level of multi-walled carbon nanotubes (MWCNT) in Chironomus riparius (DIPTERA) aquatic larvae
Autor(es) Martínez Paz, Pedro
Negri, Viviana
Esteban Arranz, Adrian
Martínez Guitarte, José Luis
Ballesteros, Paloma
Morales, Mónica
Materia(s) Ciencias
Abstract Nowadays, due to the physical, chemical, electrical, thermal and mechanical properties of carbon nanotubes (CNT), its have been currently incorporated into biomedical products and they are employed in drug delivery drug administration, biosensor design, microbial treatments, consumer products, and new products containing CNT are expected in the future. CNT are hydrophobic and have a tendency to accumulate in sediments if they are released into aquatic ecosystems. Vertebrate studies have revealed concerns about the toxicity of carbon nanotubes, but there is very limited data on the toxic effects in aquatic invertebrate species. The aim of the present study is to determine the effects of MWCNT in Chironomus riparius at the molecular level, understanding its mode of action and analyzing the suitability of this species to monitor and assess risk of nanomaterials in aquatic ecosystems. To evaluate possible toxic effects caused by carbon nanotube environmental dispersion with regard to aquatic compartment, we study the mRNA levels of several related genes with DNA repairing mechanisms, cell stress response, cell apoptosis and cytoskeleton by Real-Time PCR and proposed a freshwater invertebrate C. riparius, which is a reference organism in aquatic toxicology. The obtained results show a transcriptional alteration of some genes included in this study, indicating that different cell processes are affected and providing one the first evidences in the mechanisms of action of MWCNT in invertebrates. Moreover, this data reinforces the need for further studies to assess the environmental risk of nanomaterial to prevent future damage to aquatic ecosystems.
Palabras clave DNA repair genes
Cell apoptosis gene
Cell stress response genes
Cytoskeleton gene
Editor(es) Elsevier
Fecha 2019-04
Formato application/pdf
Identificador bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0006
http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0006
DOI - identifier https://doi.org/10.1016/j.aquatox.2019.01.017
ISSN - identifier 0166-445X; eISSN: 1879-1514
Nombre de la revista Aquatic Toxicology
Número de Volumen 209
Página inicial 42
Página final 48
Publicado en la Revista Aquatic Toxicology Volume 209, April 2019, Pages 42-48
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/closedAccess
Tipo de acceso Acceso cerrado
Notas adicionales The registered version of this article, first published in "Aquatic Toxicology Volume 209, April 2019, Pages 42-48", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.aquatox.2019.01.017 Aquatic Toxicology Volume 209, April 2019, Pages 42-48
Notas adicionales La versión registrada de este artículo, publicado por primera vez en "Aquatic Toxicology Volume 209, April 2019, Pages 42-48", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.aquatox.2019.01.017

 
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Creado: Wed, 24 Jan 2024, 22:35:44 CET