BPA and its analogues (BPS and BPF) modify the expression of genes involved in the endocrine pathway and apoptosis and a multi drug resistance gene of the aquatic midge Chironomus riparius (Diptera)

Morales, Mónica, Fuente, Mercedes de la y Martín Folgar, Raquel . (2020) BPA and its analogues (BPS and BPF) modify the expression of genes involved in the endocrine pathway and apoptosis and a multi drug resistance gene of the aquatic midge Chironomus riparius (Diptera). Environmental Pollution, Volume 265, Part A, 2020, 114806

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Título BPA and its analogues (BPS and BPF) modify the expression of genes involved in the endocrine pathway and apoptosis and a multi drug resistance gene of the aquatic midge Chironomus riparius (Diptera)
Autor(es) Morales, Mónica
Fuente, Mercedes de la
Martín Folgar, Raquel
Materia(s) Ciencias
Abstract Many countries are limiting the use of bisphenol A (BPA) because evidence shows it is dangerous to human health and wildlife. For the manufacturing of polycarbonate plastics, bisphenol S (BPS) and bisphenol F (BPF) are proposed as safer alternatives. They have already been released into the aquatic environment without previously available information about their potential adverse effects. In this study, we compared the effects of BPA, BPS and BPF exposure to the expression profile of genes involved in the endocrine pathway (EcR and E74), ecdysone metabolism (Cyp18a1 and Shadow), apoptosis (DRONC) and the multidrug resistance-associated protein 1 gene (MRP1) in the midge, Chironomus riparius (Diptera). The three toxicants increased Shadow expression, which is involved in ecdysone synthesis, but only BPF significantly altered Cyp18a1, which is implicated in ecdysone degradation. BPS and BPF modified EcR and E74 expression; BPF upregulated the effector caspase DRONC. Furthermore, BPA significantly increased MRP1 expression. This study provides insights into the action of bisphenols at the molecular level and highlights the potential risks of BPS and BPF as BPA alternatives.
Palabras clave Bisphenol A
Bisphenol S
Bisphenol F
Chironomus riparius
Toxicity
Editor(es) Elsevier
Fecha 2020-05-24
Formato application/pdf
Identificador bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0005
http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0005
DOI - identifier https://doi.org/10.1016/j.envpol.2020.114806
ISSN - identifier 0269-7491
Nombre de la revista Environmental Pollution
Número de Volumen 265
Publicado en la Revista Environmental Pollution, Volume 265, Part A, 2020, 114806
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in "Environmental Pollution, Volume 265, Part A, 2020, 114806", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.envpol.2020.114806
Notas adicionales La versión registrada de este artículo, publicado por primera vez en "Environmental Pollution, Volume 265, Part A, 2020, 114806", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.envpol.2020.114806

 
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Creado: Wed, 24 Jan 2024, 22:07:11 CET