Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo

Torres Ruiz, Mónica, Alba González, Mercedes de, Morales, Mónica, Martin Folgar, Raquel, González, Mª. Carmen, Cañas Portilla, Ana I. y Vieja, Antonio de la . (2023) Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo. Science of The Total Environment, Volume 874, 2023, 162406

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Título Neurotoxicity and endocrine disruption caused by polystyrene nanoparticles in zebrafish embryo
Autor(es) Torres Ruiz, Mónica
Alba González, Mercedes de
Morales, Mónica
Martin Folgar, Raquel
González, Mª. Carmen
Cañas Portilla, Ana I.
Vieja, Antonio de la
Materia(s) Ciencias
Abstract Nanoplastics (NP) are present in aquatic and terrestrial ecosystems. Humans can be exposed to them through contaminated water, food, air, or personal care products. Mechanisms of NP toxicity are largely unknown and the Zebrafish embryo poses an ideal model to investigate them due to its high homology with humans. Our objective in the present study was to combine a battery of behavioral assays with the study of endocrine related gene expression, to further explore potential NP neurotoxic effects on animal behavior. Polystyrene nanoplastics (PSNP) were used to evaluate NP toxicity. Our neurobehavioral profiles include a tail coiling assay, a light/dark activity assay, two thigmotaxis anxiety assays (auditory and visual stimuli), and a startle response - habituation assay in response to auditory stimuli. Results show PSNP accumulated in eyes, neuromasts, brain, and digestive system organs. PSNP inhibited acetylcholinesterase and altered endocrine-related gene expression profiles both in the thyroid and glucocorticoid axes. At the whole organismlevel, we observed altered behaviors such as increased activity and anxiety at lower doses and lethargy at a higher dose, which could be due to a variety of complex mechanisms ranging from sensory organ and central nervous system effects to others such as hormonal imbalances. In addition, we present a hypothetical adverse outcome pathway related to these effects. In conclusion, this study provides new understanding into NP toxic effects on zebrafish embryo, emphasizing a critical role of endocrine disruption in observed neurotoxic behavioral effects, and improving our understanding of their potential health risks to human populations.
Palabras clave Nanomaterial
Plastic
Development
Toxicity
Behavior
Hormones
Editor(es) Elsevier
Fecha 2023-05-20
Formato application/pdf
Identificador bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0001
http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Mmorales-0001
DOI - identifier https://doi.org/10.1016/j.scitotenv.2023.162406
ISSN - identifier 0048-9697; e-ISSN: 1879-1026
Nombre de la revista Science of The Total Environment
Número de Volumen 874
Publicado en la Revista Science of The Total Environment, Volume 874, 2023, 162406
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in "Science of The Total Environment, Volume 874, 2023, 162406", is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.scitotenv.2023.162406
Notas adicionales La versión registrada de este artículo, publicado por primera vez en "Science of The Total Environment, Volume 874, 2023, 162406", está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.scitotenv.2023.162406

 
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Creado: Wed, 24 Jan 2024, 20:01:38 CET