Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.

Romero-Miguel, D., Casquero-Veiga, M., Fernández, J., Lamanna-Rama, N., Gómez-Rangel, V., Gálvez-Robleño, C., Santa Marta Pastrana, Cristina, Villar, C. J., Lombó, F., Abalo, R., Desco, M. y Soto-Montenegro, M. L. . (2023) Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.. Antioxidants

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Título Maternal Supplementation with N-Acetylcysteine Modulates the Microbiota-Gut-Brain Axis in Offspring of the Poly I:C Rat Model of Schizophrenia.
Autor(es) Romero-Miguel, D.
Casquero-Veiga, M.
Fernández, J.
Lamanna-Rama, N.
Gómez-Rangel, V.
Gálvez-Robleño, C.
Santa Marta Pastrana, Cristina
Villar, C. J.
Lombó, F.
Abalo, R.
Desco, M.
Soto-Montenegro, M. L.
Materia(s) Zoología
Abstract The microbiota-gut-brain axis is a complex interconnected system altered in schizophrenia. The antioxidant N-acetylcysteine (NAC) has been proposed as an adjunctive therapy to antipsychotics in clinical trials, but its role in the microbiota-gut-brain axis has not been sufficiently explored. We aimed to describe the effect of NAC administration during pregnancy on the gut-brain axis in the offspring from the maternal immune stimulation (MIS) animal model of schizophrenia. Pregnant Wistar rats were treated with PolyI:C/Saline. Six groups of animals were studied according to the study factors: phenotype (Saline, MIS) and treatment (no NAC, NAC 7 days, NAC 21 days). Offspring were subjected to the novel object recognition test and were scanned using MRI. Caecum contents were used for metagenomics 16S rRNA sequencing. NAC treatment prevented hippocampal volume reduction and long-term memory deficits in MIS-offspring. In addition, MIS-animals showed lower bacterial richness, which was prevented by NAC. Moreover, NAC7/NAC21 treatments resulted in a reduction of proinflammatory taxons in MIS-animals and an increase in taxa known to produce anti-inflammatory metabolites. Early approaches, like this one, with anti-inflammatory/anti-oxidative compounds, especially in neurodevelopmental disorders with an inflammatory/oxidative basis, may be useful in modulating bacterial microbiota, hippocampal size, as well as hippocampal-based memory impairments.
Palabras clave Poly I:C
schizophrenia
microbiota-gut-brain axis
inflammation
oxidative stress
Editor(es) MDPI
Fecha 2023-04-20
Formato application/pdf
Identificador bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008
http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0008
DOI - identifier 10.3390/ANTIOX12040970
ISSN - identifier 2076-3921
Nombre de la revista Antioxidants
Número de Volumen 12
Número de Issue 4
Publicado en la Revista Antioxidants
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Antioxidants, is available online at the publisher's website: http://hdl.handle.net/10017/12601 MDPI https://doi.org/10.3390/ANTIOX12040970
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Antioxidants, está disponible en línea en el sitio web del editor: MDPI https://doi.org/10.3390/ANTIOX12040970

 
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Creado: Fri, 26 Jan 2024, 03:50:52 CET