N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration.

Molina, Vicente, Sánchez, Javier, Reig, Santiago, Sanz, Javier, Benito, Carlos, Santa Marta Pastrana, Cristina, Pascau, Javier, Sarramea, Fernando, Gispert, Juan D., Misiego, José M., Palomo, Tomás y Desco, Manuel . (2005) N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration.. Schizophrenia Research

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Título N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration.
Autor(es) Molina, Vicente
Sánchez, Javier
Reig, Santiago
Sanz, Javier
Benito, Carlos
Santa Marta Pastrana, Cristina
Pascau, Javier
Sarramea, Fernando
Gispert, Juan D.
Misiego, José M.
Palomo, Tomás
Desco, Manuel
Materia(s) Biomedicina
Abstract Magnetic resonance spectroscopy studies in schizophrenia have revealed consistently reduced N-acetyl aspartate (NAA) levels in chronic patients, but not in recent-onset patients. Studies on the relationship between this marker and disease duration have commonly been negative, although it is also true that they have been conducted in patients with long-standing disease. We compared NAA levels in the dorsolateral prefrontal cortex in 16 recent-onset patients (duration: 1.8±0.6 years), 19 chronic patients (duration: 9.7±6.1 years), and 20 healthy controls. We studied the NAA/creatine and choline/creatine ratios in the dorsolateral prefrontal cortex in both hemispheres, controlling for the effect of age. Chronic patients had significantly lower NAA/Cr ratios in the left hemisphere compared to recent-onset patients and healthy controls, with no difference in Cho/Cr ratio. There were no differences between controls and recent-onset patients. There was a significant inverse relationship between left-side NAA/Cr and disease duration, suggesting that prefrontal NAA levels may progressively decrease in schizophrenia. Taken within the context of the existing literature, these results indicate that this process may be limited to the early years following the onset of the disease. Therefore, reduced prefrontal levels of NAA may be limited to chronic schizophrenia patients.
Palabras clave N-acetyl aspartate
Schizophrenia
Prefrontal lobe
MRS
Neurodegeneration
Disease duration
Editor(es) Elsevier
Fecha 2005-03-01
Formato application/pdf
Identificador bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0004
http://e-spacio.uned.es/fez/view/bibliuned:DptoFMyF-FCIE-Articulos-Csantamarta-0004
DOI - identifier 10.1016/j.schres.2004.02.001
ISSN - identifier 0920-9964
Nombre de la revista Schizophrenia Research
Número de Volumen 73
Número de Issue 2-3
Página inicial 209
Página final 219
Publicado en la Revista Schizophrenia Research
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Schizophrenia Research, is available online at the publisher's website: Elsevier https://doi.org/10.1016/J.SCHRES.2004.02.001
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Schizophrenia Research, está disponible en línea en el sitio web del editor: Elsevier https://doi.org/10.1016/J.SCHRES.2004.02.001

 
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Creado: Fri, 26 Jan 2024, 04:21:08 CET