Development of a molecularly imprinted polymeric membrane for determination of macrolide antibiotics from cow milk

Cañadas Soler, Raquel, Garcinuño, Rosa María, Paniagua González, Gema y Fernández Hernando, Pilar . (2022) Development of a molecularly imprinted polymeric membrane for determination of macrolide antibiotics from cow milk. Polymer 249, (2022)

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Título Development of a molecularly imprinted polymeric membrane for determination of macrolide antibiotics from cow milk
Autor(es) Cañadas Soler, Raquel
Garcinuño, Rosa María
Paniagua González, Gema
Fernández Hernando, Pilar
Materia(s) Ciencias
Abstract A molecular imprinted membrane (MIM) was prepared for the selective binding of macrolide antibiotics by UV-initiated non-covalent imprinting approach . The membrane was modified by a UV - photographting technique in the presence of molecule templates of erythromycin (ERY) and spiramycin (SPI) with methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinker. The nanofunctionalized MIM obtained was characterized by a morphological study using scanning electron microscopy (SEM), as well as by a study of its adsorption capacity by online solid phase extraction (SPE) procedure. Variables affecting the MIM-SPE method were optimized to maximize the extraction of macrolide antibiotics of interest and a high-performance liquid chromatography (HPLC) method was used for the analysis. Good linearity and precision were obtained for ERY and SPI, with average recoveries up to 86.14 % and 34.73 %, respectively, with a relative standard deviation (RSD) lower than 6 %. In addition, selectivity was studied for other macrolides with similar structure to the templates, such as roxithromycin (ROX), josamycin (JOS), ivermectin (IVER) and tylosin (TYL). The proposed MIM-SPE-HPLC methodology was effectively applied to ERY and SPI determination in commercial doped semi-skimmed cow’s milk samples.
Palabras clave Molecularly imprinted membrane
Macrolide antibiotics
Cow milk
Editor(es) Elsevier
Fecha 2022-05-17
Formato application/pdf
Identificador bibliuned:DptoCA-FCIE-Articulos-Gpaniagua-003
http://e-spacio.uned.es/fez/view/bibliuned:DptoDptoCA-FCIE-Articulos-Gpaniagua-003
DOI - identifier https://doi.org/10.1016/j.polymer.2022.124843
fecha fin de embargo 2024-05-18
ISSN - identifier 0032-3861 - eISSN: 1873-2291
Nombre de la revista Polymer
Número de Volumen 249
Publicado en la Revista Polymer 249, (2022)
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Polymer, is available online at the publisher's website: https://doi.org/10.1016/j.polymer.2022.124843
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Polymer, está disponible en línea en el sitio web del editor: https://doi.org/10.1016/j.polymer.2022.124843

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Creado: Wed, 10 Jan 2024, 22:53:12 CET