An optical sensor for the determination of digoxin in serum samples based on a molecularly imprinted polymer membrane.

Paniagua González, Gema, Fernández Hernando, Pilar y Durand Alegría, J. S. . (2009) An optical sensor for the determination of digoxin in serum samples based on a molecularly imprinted polymer membrane.. Analytica Chimica Acta 638 (2009), 209-212.

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Título An optical sensor for the determination of digoxin in serum samples based on a molecularly imprinted polymer membrane.
Autor(es) Paniagua González, Gema
Fernández Hernando, Pilar
Durand Alegría, J. S.
Materia(s) Ciencias
Abstract This paper reports the synthesis and testing of a molecularly imprinted polymer membrane for digoxin analysis. Digoxin-specific bulk polymer was obtained by the UV initiated co-polymerisation of methacrylic acid and ethylene glycol dimethacrylate in acetonitrile as porogen. After extracting the template analyte, the ground polymer particles were mixed with plasticizer polyvinyl chloride to form a MIP membrane. A reference polymer membrane was prepared from the same mixture of monomers but with no template. The resultant membrane morphologies were examined by scanning electron microscopy. The imprinted membrane was tested as the recognition element in a digoxin-sensitive fluorescence sensor; sensor response was measured using standard solutions of digoxin at concentrations of up to 4 × 10−3 mg L−1. The detection limit was 3.17 × 10−5 mg L−1. Within- and between-day relative standard deviations RSD (n = 5) were in the range 4.5–5.5% and 5.5–6.5% respectively for 0 and 1 × 10−3 mg L−1 digoxin concentrations. A selectivity study showed that compounds of similar structure to digoxin did not significantly interfere with detection for interferent concentrations at 10, 30 and 100 times higher than the digoxin concentration. This simply manufactured MIP membrane showed good recognition characteristics, a high affinity for digoxin, and provided satisfactory results in analyses of this analyte in human serum.
Palabras clave Molecularly imprinted polymer
Affinity membrane
Digoxin
Organic sample analysis
Editor(es) Elsevier
Fecha 2009-04
Formato application/pdf
Identificador bibliuned:DptoCA-FCIE-Articulos-Gpaniagua-0012
http://e-spacio.uned.es/fez/view/bibliuned:DptoCA-FCIE-Articulos-Gpaniagua-0012
DOI - identifier https://doi.org/10.1016/j.aca.2009.02.023
ISSN - identifier 0003-2670 - eISSN 1873-4324
Nombre de la revista Analytica Chimica Acta
Número de Volumen 638
Página inicial 209
Página final 212
Publicado en la Revista Analytica Chimica Acta 638 (2009), 209-212.
Idioma eng
Versión de la publicación acceptedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Analytica Chimica Acta, is available online at the publisher's website: Elsevier, https://doi.org/10.1016/j.aca.2009.02.023
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Analytica Chimica Acta, está disponible en línea en el sitio web del editor: Elsevier, https://doi.org/10.1016/j.aca.2009.02.023

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