Integrative Base Ontology for the Research Analysis of Alzheimer’s Disease-Related Mild Cognitive Impairment

Gómez-Valadés Batanero, Alba, Martínez Tomás, Rafael y Rincón, Mariano . (2021) Integrative Base Ontology for the Research Analysis of Alzheimer’s Disease-Related Mild Cognitive Impairment. Frontiers in Neuroinformatics

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Título Integrative Base Ontology for the Research Analysis of Alzheimer’s Disease-Related Mild Cognitive Impairment
Autor(es) Gómez-Valadés Batanero, Alba
Martínez Tomás, Rafael
Rincón, Mariano
Materia(s) Ingeniería Informática
Abstract Early detection of mild cognitive impairment (MCI) has become a priority in Alzheimer’s disease (AD) research, as it is a transitional phase between normal aging and dementia. However, information on MCI and AD is scattered across different formats and standards generated by different technologies, making it difficult to work with them manually. Ontologies have emerged as a solution to this problem due to their capacity for homogenization and consensus in the representation and reuse of data. In this context, an ontology that integrates the four main domains of neurodegenerative diseases, diagnostic tests, cognitive functions, and brain areas will be of great use in research. Here, we introduce the first approach to this ontology, the Neurocognitive Integrated Ontology (NIO), which integrates the knowledge regarding neuropsychological tests (NT), AD, cognitive functions, and brain areas. This ontology enables interoperability and facilitates access to data by integrating dispersed knowledge across different disciplines, rendering it useful for other research groups. To ensure the stability and reusability of NIO, the ontology was developed following the ontology-building life cycle, integrating and expanding terms from four different reference ontologies. The usefulness of this ontology was validated through use-case scenarios.
Palabras clave ontology
MCI
Alzheimer’s disease
neuropsychological tests
neurodegenerative disease
ontology design
Editor(es) Frontiers
Fecha 2021-02-04
Formato application/pdf
Identificador bibliuned:95-Rmartinez-0003
http://e-spacio.uned.es/fez/view/bibliuned:95-Rmartinez-0003
DOI - identifier 10.3389/fninf.2021.561691
ISSN - identifier 1662-5196
Nombre de la revista Frontiers in Neuroinformatics
Número de Volumen 15
Publicado en la Revista Frontiers in Neuroinformatics
Idioma eng
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
Tipo de acceso Acceso abierto
Notas adicionales The registered version of this article, first published in Frontiers in Neuroinformatics, is available online at the publisher's website: Frontiers https://doi.org/10.3389/fninf.2021.561691
Notas adicionales La versión registrada de este artículo, publicado por primera vez en Frontiers in Neuroinformatics, está disponible en línea en el sitio web del editor: Frontiers https://doi.org/10.3389/fninf.2021.561691

 
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Creado: Fri, 26 Jan 2024, 23:46:46 CET