On the impartiality of early British clinical trials

Teira Serrano, David . (2013) On the impartiality of early British clinical trials. Studies in History and Philosophy of Biological and Biomedical Sciences

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Título On the impartiality of early British clinical trials
Autor(es) Teira Serrano, David
Resumen Did the impartiality of clinical trials play any role in their acceptance as regulatory standards for the safety and efficacy of drugs? According to the standard account of early British trials in the 1930s and 1940s, their impartiality was just rhetorical: the public demanded fair tests and statistical devices such as randomization created an appearance of neutrality. In fact, the design of the experiment was difficult to understand and the British authorities took advantage of it to promote their own particular interests. I claim that this account is based on a poorly defined concept of experimental fairness (derived from T. Porter’s ideas). I present an alternative approach in which a test would be impartial if it incorporates warrants of non-manipulability. With this concept, I reconstruct the history of British trials showing that they were indeed fair and this fairness played a role in their acceptance as regulatory yardsticks.
Palabras clave clinical trials, Streptomycin, fair test, impartiality
Fecha 2013-06-04
Formato application/pdf
Identificador bibliuned:500681
Publicado en la Revista Studies in History and Philosophy of Biological and Biomedical Sciences
Versión de la publicación publishedVersion
Tipo de recurso Article
Derechos de acceso y licencia http://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
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Creado: Tue, 04 Jun 2013, 12:17:28 CET